肝硬化患者体表胃电参数与肝功能Child-Pugh分级关系的研究

The investigation of relationship between cutaneous electrogastrogram parameters and the grades of liver function according to Child-Pugh's score criterion in patients with cirrhosis of the liver

目的探讨体表胃电图参数与消化道相关症状之间的联系。方法选择肝硬化患者62例,其中A级为18例;B级为24例;C级为20例。同时选择20例正常志愿者为对照组。胃电图检测记录包括空腹及进食试餐后不同慢波节律的百分比、主频(DF)、主功率(DP)、餐后/餐前功率比(PR)几项数据,进行对比分析。计量资料采用配对t检验和单因素方差分析;组间比较采用最小显著差法(LSD)。结果①健康组、肝硬化组DF分别为3.0±0.21cpm、2.8±0.23cpm;DP分别为46.35±5.19dB、43.71±3.47dB;N%分别为49.23±12.71%、36.27±8.99%;PR分别为1.16±0.11、1.09±0.06。肝硬化组DF、DP、N%、PR平均值均低于对照组,有显著性差异。②肝硬化3组中N%分别为(41.08±5.96)%、(34.99±11.65)%、(33.48±5.59)%;Child-Pugh分级A级与B级、C级间有显著性差异。PR分别为1.12±0.02、1.09±0.04、1.05±0.07。Child-Pugh分级A、B、C三组中C级与A级间差异有统计学意义。结论①肝硬化组较对照组相比其DF、N%、PR明显下降,提示肝硬化患者存在胃电节律紊乱。②Child-Pugh分级A、B、C级三组N%、PR依次降低,证明肝脏的损害越重,其胃电异常改变越明显。

Objective To research the relationship between EGG and the symptoms related to digestive system in those cases.Method We treated 62 patients,All cases were diagnosed as cirrhosis of the liver.according to Child-Pugh＇s score criterion,18 cases were classified as grade A,24 as B,and 20 as C,and 20 healthy volunteers..The indexes of EGG included Dominant frequeney （DF）、 Dominant Power （DP）、 percentage of normal electrogastric slow wave、the power ratio between empty and full,etc,in hunger and in repletion,respectively.With t-test and One way Analysis of Variance （ANOV） were employed in analyzing the measurement data.Results ①DF[（2.8±0.23 cpm）vs.（3.0±0.21 cpm）],DP[（43.71±3.47 dB） vs.（46.35±5.19dB）],N% [（36.27±8.99%） vs.（49.23±12.71%）],and PR [（1.09±0.06） vs.（1.16±0.11）] are lower in cirrhotic patients than that of the normal controls （P 〈0.05）.②N% in Child-Pugh B patients （34.99±11.65%） and in Child-Pugh C （33.48±5.59%） are lower than that in Child-Pugh A （41.08±5.96%） （P 〈0.05）.PR in Child-Pugh C patients（1.05±0.07） are lower than that in Child-Pugh A （1.12±0.02） （P 〈0.05）.Conclusions ①DF,DP,N% and PR in cirrhotic patients are lower than that of the normal controls.Cirrhosis patients are in gastric myoelectrical dysrhythmia.② Abnormal gastric myoelectrical activity in cirrhosis is more obvious in those with more severe liver dysfunction.