3Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic selftolerance maintained by activated T cells expressing IL-2 receptor alphachains (CD25). Breakdown of a single mechanism of selftolerance causes various autoimmune diseases[J]. J Immunol, 1995, 155(3): 1151-1164.
4Bruder D,ProbstKepper M,Westendorf AM, et al. Neuropilin-1: a surface marker of regulatory T cells[J]. Eur J Immunol, 2004, 34(3): 623-630.
5Peng Y, Laouar Y, Li MO, et al.TGF-beta regulates in vivo expansion of Foxp3expressing CD4^+CD25^+regulatory T cells responsible for protection against diabetes[J]. Proc Natl Acad Sci USA, 2004, 101(13): 4572-4577.
6Brunkow ME, Jeffery EW, Hjerrild KA, et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse[J]. Nat Genet, 2001, 27(1): 68-73.
7Morgan ME, van Bilsen JH, Bakker AM, et al. Expression of FOXP3 mRNA is not confined to CD4^+CD25^+ T regulatory cells in humans[J]. Human Immunol, 2005, 66(1): 13-20.
8Chatila TA, Blaeser F,Ho N, et al.Jm2 encoding a fork headrelated protein, is mutated in X-linked autoimmunityallergic disregulation syndrome[J]. J Clin Invest, 2000, 106(12): R75-81.
9Hori S,NomuraT, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3[J]. Science, 2003, 299(5609): 1057-1061.
10Kim JY, Kim HJ, Hurt EM, et al. Functional and genomic analyses of FOXP3-transduced Jurkat-T cells as regulatory T (Treg)-like cells[J]. Biochem Biophys Res Commun, 2007, 362(1): 44-50.
4Kaplan MM, Gershwin ME. Primary biliary cirrhosis [J]. N Engl J Med, 2005, 353: 1261 -1273.
5Heathcote EJ . Management of primary biliary cirrhosis. The American Association for the Study of Liver Diseases practice guidelines[J]. J Hepatol, 2000, 31: 1005 -1013.
6Carr SA, Celis JE. Biomarkers and clinical proteomics [ J ]. Mol Cell Proteomics, 2006, 5(10): 17-19.
7Leung SM, Mok SC. Quality management of ovarian cancer serum profiles using functionalized magnetic beads, anchorchip TM technology, MALDI -TOF MS and MALDI -TOF - TOF MS/MS[R]. AACR Annual Meeting, 2004.
8Cheng AJ, Chen LC, Chien KY, et al. Oral cancer plasma tumor marker identified with bead -based affinity-fractionated proteomic technology [ J ]. Clin Chem, 2005, 51 (12): 2236 -2244.
9Wulfkuhle JD, Liotta LA, Petricoin EF. Proteomic applications for the early detection of cancer [J]. Nat Rev Cancer, 2003, 3 (4): 267 -275.
10Li YZ, Hu C J, Leng XM, et al. Promising diagnostic biomarkers for primary biliary cirrhosis identified with magnetic beads and MALDI - TOF - MS [J]. Anat Rec, 2009, 292 (3): 455 -460.