10例妊娠急性脂肪肝临床分析

Clinical Analysis of Acute Fatty Liver in Pregnancy

目的探讨妊娠急性脂肪肝患者的早期临床特点及治疗和预后。方法对2003年12月—2008年12月来我院治疗的10例妊娠急性脂肪肝患者临床资料进行回顾性分析。结果患者在孕晚期多数表现为乏力、厌食、恶心、呕吐和黄疸,实验室检查表现为白细胞升高、肝肾功能损害和凝血功能损害,并发症主要为凝血功能障碍、产后出血、肝性脑病和产褥感染等。结论重视妊娠晚期出现的消化道症状,早期诊断和治疗可明显改善预后结局,其关键是及时行宫产术终止妊娠,积极进行内科综合治疗。

OBJECTIVE To investigate the acute fatty liver of pregnancy in patients with early clinical characteristics and treatment and prognosis. METHODS Jiande City MCH from December 2003 to December 2008 5 years 10 cases of acute fatty liver of pregnancy （AFLP）clinical data were retrospectively analyzed. RESULTS At the majority of patients with third trimester of pregnancy manifested in fatigue, anorexia, nausea, vomiting, jaundice, laboratory tests showed elevated leukocyte, liver and kidney function impairment, coagulation dysfunction, complications mainly coagulation dysfunction, post -partum haemorrhage and hepatic encephalopathy encephalopathy, puerperal infection, etc. CONCLUSIONS Importance of the digestive tract occur in late pregnancy symptoms, early diagnosis and treatment can significantly improve the prognosis of the outcome, with a focus on timely cesarean section and positive medical termination of pregnancy combined treatment.