加替沙星序贯疗法和输液疗法治疗下呼吸道感染的临床比较

The Comparison of Gatifloxacin Sequential Method Versus Transfusion Method on Lower Respiratory Tract Infection

目的比较加替沙星序贯疗法和输液疗法治疗下呼吸道感染的临床疗效。方法2008年6月—2009年6月下呼吸道感染患者124例,随机分为加替沙星序贯疗法组和输液疗法组,每组62例,对比观察两组的临床疗效、恢复指标及不良反应。结果序贯疗法组与输液疗法组总有效率比较,差异无统计学意义(P>0.05)。序贯组与输液疗法组平均退热时间、平均咳嗽消失时间、平均罗音消失时间及平均治愈时间比较,差异无统计学意义(P>0.05)。序贯组的不良反应发生率明显少于输液组(P<0.05)。结论加替沙星序贯疗法和输液疗法疗效相当,但不良反应发生率低,值得临床推广应用。

OBJECTIVE To compare the clinical efficacy of gatifloxacin sequential method versus transfusion method on lower respiratory tract infection. METHOD From June 2008 to June 2009, 124 cases of lower respiratory tract infection patients were divided into two groups, which sequential method group with 62 cases and transfusion method group with 62 cases. The clinical efficacy, recover indexes and adverse effect of the two groups were compared. RESULTS There was no significant difference in clinical efficacy, average pyretolysis time, average cough extinction time, average rales extinction time and average curing time between the two groups（P0.05）. The rates of adverse effect in sequential method group were significantly lower than that in transfusion method group （P0.05）. CONCLUSION The gatifloxacin sequential method is equal to transfusion method in clinical effect but lower adverse effect in treatment with lower respiratory tract infection.