二叠氮桥二[4-硝基-2-(3′-二甲胺基丙基亚胺基)亚甲基苯酚]合双核锌(Ⅱ)的合成、晶体结构及细胞毒性

Synthesis,crystal structure and cytotoxic property of diazide-bis[4-nitro-2-(3′-dimethylamino-n-propylimino) methylenephenolate] dizinc(Ⅱ)

以叠氮桥联基团配合双核席夫碱锌(Ⅱ)合成了标题化合物,并利用元素分析、红外光谱和单晶X-射线衍射等分析方法表征了其结构。该标题配合物的晶体属于单斜晶系,空间群为P2(1)/n,晶胞参数分别为:a=8.736(2),b=14.850(3),c=11.775(2),β=102.42(3)°,晶胞体积V=1 491.8(5)3,一个晶胞所含的分子数Z=2,晶体密度Dc=1.593 g/cm3,相对分子质量Mr=715.36,X-射线波长λ(MoKα)=0.710 73,晶体的线性吸收系数μ=1.669 mm-1,晶胞中电子数目F(000)=736,最终的残差因子为R=0.033 8和wR=0.078 9。在测试过程中,总共收集了3 411个独立衍射点,其中可观测衍射点(I>2σ(I))的数目为2 777个。该配合物分子具有晶体学反演中心。配合物中的每个Zn原子都是由一个席夫碱配体和两个叠氮配体进行配位的,形成五配位三角双锥构型。Zn…Zn距离为3.328(2)。在配合物的晶体结构中,分子间通过C—H…N氢键作用连接在一起,进而形成平行于bc平面的层状结构。该配合物对于正常细胞和癌细胞均具有低的细胞毒性。

The title azide-bridged dinuclear Schiff base zinc（Ⅱ） complex was prepared and characterized by elemental analysis,IR spectroscopy,and single-crystal X-ray diffractometry.The crystal belonged to a monoclinic system,with a space group P2（1）/n.The cell parameters were：a=8.736（2）,b=14.850（3）,c=11.775（2）,β=102.42（3）°,V=1 491.8（5）3,Z=2,Dc=1.593 g/cm3,Mr=715.36,λ（MoKα）=0.710 73,μ=1.669 mm-1,F（000）=736,and the final R=0.033 8 and wR=0.078 9.A total of 3 411 unique reflections were collected,of which 2 777 with I2σ（I） were observed.The molecule of the complex was located on a crystallographic inversion centre.Each Zn atom in the complex was five-coordinated by one Schiff base ligand and two bridging azide groups to form a trigonal bipyramidal configuration.The Zn…Zn distance was 3.328（2）.In the crystal structure,molecules were linked through intermolecular C—H…N hydrogen bonds to form layers parallel to the bc plane.The complex showed low cytotoxicity to both normal and carcinoma cells.