雌甾-3-甲氧基-2,5(10)-二烯-17-酮的合成研究

Study on the Synthesis of Estra-3-methoxy-2,5(10)-dien-17-one

目的:研究雌甾-3-甲氧基-2,5(10)-二烯-17-酮(B)的最佳合成工艺。方法:以雌甾-3-甲氧基-2,5(10)-二烯-17-醇(A)为原料,分别运用沃氏氧化、活性二氧化锰和Collins试剂为氧化剂对其进行氧化反应,以得到标题化合物,并比较三种合成方法。结果与讨论:在以雌甾-3-甲氧基-2,5(10)-二烯-17-醇(A)为原料合成标题化合物的方法中,以沃氏氧化为最佳。

Objective： To study the best synthetic method ofestra-3-methoxy-2,5（10）-dien-17-one（B）. Method： The target compound was synthesized from estra-3-methoxy-2,5（10）-dien-17-ol（A）by three different oxidations in compari- son, including Oppenauer oxidation, oxidation with activated manganese dioxide and oxidation with Collins reagent. Result and conclusion： Taking estra-3-methoxy-2,5（ 10）-dien-17-ol as starting material, Oppenauer oxidation is the best method to synthesize estra-3-methoxy-2,5（10）-dien-17-one.