青年乳腺癌ER、CerbB-2、XIAP、Smac表达情况的临床特征及意义

Clinical Features and Significance of Expression of ER、CerbB-2、XIAP、Smac in Young Patients with Breast Cancer

目的:探讨青年乳腺癌中ER、CerbB-2、XIAP、Smac表达情况的临床特征及其意义。方法:应用免疫组化SP法检测32例青年乳腺癌的ER、CerbB-2、XIAP、Smac的表达情况,与同期住院年龄≥40岁的乳腺癌中随机抽取44例相比较。结果:32例青年乳腺癌中ER、CerbB-2、XIAP、Smac阳性表达率分别是43.8%(14/32)、62.5%(20/32)、78.1%(25/32)、34.4%(11/32)。中老年乳腺癌ER、CerbB-2、XIAP、Smac阳性表达率分别是72.7%(32/44)、31.8%(14/44)、54.5%(24/44)、61.4%(27/44)。青年乳腺癌的ER、Smac表达低于中老年乳腺癌,CerbB-2、XIAP表达高于中老年乳腺癌。结论:青年乳腺癌侵袭性强,恶性程度高,预后差。这不但与ER、CerbB-2的表达不同有关,青年乳腺癌的细胞调亡受到抑制也是重要原因之一,应对青年乳腺癌患者充分重视。

Objective：To Discuss the clinical features and significance of the expression of ER.CerbB-2.XIAP. Smac in young patients with breast cancer. Methods： Using Immunity histoehemistry SP, the expression of ER. CerbB-2.XIAP.Smac of 32 young patients with breast cancer was examined,and compared with 44 cases of breast cancer whose age were over 40 years old in the hospital in the same time. Result： The expression of ER.CerbB-2 .XIAP,Smac in young patients with breast cancer was 43.8%（14/32）,62. 50//00（20/32）,78. 1%（25/32）,34.40/00 （11/ 32）. The expression of ER,CerbB-2 ,XIAP,Smac in control group was 72.7 G （32/44）,31.8%（14/44）,54.5 ~/00 （24/ 44） ,61.4%（27/44）. The expression of ER,Smac in the young patients with breast cancer was lower than control group, but the expression of CerbB-2,XIAP was higher. Conclusion：The young patients with breast cancer have the parameter of strong invasion, the high degree of malignant, and poor prognostic. That not only because of the different expression of the ER, CerbB 2, but also apoptosis of the young patients with breast cancer is suppressed. The young breast cancer patients should be full attention.