单用氨苯砜治愈的麻风患者采用联合化疗抗复发的研究

Study on Anti-relapse of Leprosy Treated with Combined Chemotherapy

目的：为了减少单用氨苯砜（DDS）治愈的麻风患者的复发。方法：1987～1991年用WHO—MDT方案分批对1971～1985年DDS单疗治愈的部分麻风病人进行6个月复治。结果：经6～10年观察，MB病人经抗复发治疗的231例病人的复发率1．30％（1．76％。人年）；未经抗复发治疗的320例病人的复发率7．50％（6．54％0人年）；MB总复发率4．04％（4．64％。人年），复治组病人的复发率显著低于后两者（P＜0．01、0．05）。PB病人经抗复发治疗的212例病人至今未见复发病例，未复治的416例复发11例，复发率2．64％（3．05％0人年）。结论：用MDT方案6个月复治能有效减少DDS单疗治愈病人的复发。

OBJECTIVE To reduce relapse of leprosy cured only with DDS. METHODS 231 cases were retreated with combined chemotherapy by Method-WHO-MDT for 6 months during 1987-1991. RESULTS After6-10 years of treatment, the total recurrence rate was 4. 04% (27/668) for MB patients. The recurrence ratewas only 1. 3% (3/231) with anti-relapse therapy and 7. 5% (24/320) without that. 212 PB-cases with antirelapse therapy do not relapsed until now and recurrence rate was 2. 64% (11/416) without the therapy. Recurrence rate with anti-relapse therapy was lower than that without the therapy. CONCLUSION The relapse ofleprosy cured only with DDS is able to be reduced by anti-relapse therapy with Method-MDT for 6 months.