成人胃食管反流病临床特点分析

Analysis on the Clinical Characteristics of Gastroesophageal Reflux Disease(GERD)in Adults

目的通过总结60例胃食管反流病(GERD)患者临床症状特点,为进一步探讨其诊断和有效治疗提供依据。方法分析患者有反酸、反食、胃灼热、非心源性胸痛、胃食管反流症状及咽喉炎、慢性咳嗽、哮喘等食管外症状,经胃镜检查分为非糜烂性食管炎(NERD)组和反流性食管炎(RE)组的发生率及发生情况。结果NERD和RE分别占GERD的53.3%和46.7%:与RE组相比,NERD患者以男性多见(P<0.05),平均年龄较轻(P<0.05)。胃食管反流症状评分在两组患者间差异无统计学意义(P>0.05),而两组患者胃灼热更突出。两组患者的食管外症状较轻。结论应密切关注患者胃灼热、反酸、反食、胸骨后疼痛症状以及食管外症状,及早诊断及早治疗。

Objective To sum up the characteristics of clinical symptoms of 60 cases of gastroesophageal reflux disease（GERD）so as to further explore the evidences of the diagnosis and treatment. Methods The gastroensophageal reflux symptoms,such as acid reflux,food reflux,gastric burning sensation and non-cardiac chest pain,as well as extra-esophageal symptoms,such as laryngitis,chronic cough and asthma were analyzed. By gastroscopy test,non-erosive esophagitis（NERD）group and reflux esophagitis（RE）group were divided. The incidences of them and the situations were analyzed. Results The percentages of NERD and RE were 53.3% and 46.7% in GERD respectively. Compared with RE group,more males suffered from NERD（P0.05）and the average age was young（P0.05）. There was no significant difference in the scales of gastroesophageal symptoms between two groups（P0.05）,but gastric burning sensation was predominated in either group. The extra-esophageal symptoms were mild in both groups. The clinical efficacy and the improvement in clinical symptoms in the treatment group were significantly better than those in the control group. Conclusion The symptoms like gastric burning sensation,acid reflux,food reflux and post-sternum pain as well as extra-esophageal symptoms should be paid close attention for early diagnosis and treatment.