摘要
目的探讨放疗联合化疗治疗复发直肠癌的临床效果。方法对２９例根治术后复发的直肠癌进行了放射治疗，其中１６例同时给予大剂量醛氢叶酸（ＣＦ），氟脲嘧啶（５ＦＵ）的全身化疗（观察组），１３例为单纯放疗（对照组）。结果观察组中局部症状缓解率较对照组高，两组有效率分别为８１．２５％、４６．１６％，有显著性差异（Ｐ＜０．０５），完全缓解分别为１８．７５％、７．６９％。两组放疗引起的局部毒性反应相似。结论ＣＦ／５Ｆｕ配合放射治疗复发直肠癌可提高近期疗效，尤其对于伴远外转移患者为理想、安全的治疗手段。
Objective To approach the clinical effects of radiotherapy and chemotherapy for recurrence of rectal carcinoma.Metheds 29 patients with recurrent rectal carcinoma were treated with radiotherapy,16 of them plus leucovorin(CF)/5 FU(study group),13 cases were treated with radiotherapy alone(control group).Results The remission rate of symptoms was higher in study group than that in control group.The response rate was 81.75% and 46.15%,respectively(P<0.05).The local toxic reaction of radiotherapy was similar in both groups.Conclusion The chemotherapy elevate the therapeutic effect for recurrent rectal carcinoma and be especially suitable for patients with metastasis.
