腰椎间盘突出症患者脑脊液胱抑蛋白C水平研究

The study of cystatin C in the cerebrospinal fluid of patients with lumbar disc herniation

目的对腰椎间盘突出症患者的脑脊液胱抑蛋白C水平进行研究，以了解其与腰椎间盘突“；症之间的关系。方法选取2006年4月至2008年12月于笔者所在医院治疗的39例腰椎间盘突出症患者为研究对象，将其分为腰椎间盘膨出组（A组）13例、腰椎间盘突出组（B组）13例和腰椎间盘脱出组（C组）13例，同时选取健康对照组（D组）13例，对所有人员的脑脊液胱抑蛋白C水平进行检测后，将结果进行研究比较。结果经研究比较发现，D组的脑脊液胱抑蛋F1C水平明显低于其他三组（P〈0．01），而A、B、C三组之间比较，C组明显高于A组与13组（P〈0．05），A组与B组比较，差异不大（P〉0．05）。同时发现其与其他因素也有关系。结论腰椎间盘突出症患者的脑脊液胱抑蛋白C水平明显高于健康人群，且腰椎间盘脱出型水平尤其高，值得临床进一步研究。

Objective To study the level of cystatin C in the cerebrospinal fluid of patients with lumbar disc herniation in order to understand the relationship between the cystatin C in the cerebrospinal fluid and lumbar disc herniation. Methods 39 patients with lumbar disc herniation in our hospital from April 2006 to December 2008 were selected as research object and was divided into three groups randomly. The lumbar intervertebral disc bulge group （A group ）were 13 cases, the slipped disc group （B group）were 13 cases, and the lumbar herniated disk group （C group）were 13 cases too. At the same time, 13 cases healthy person were selected as control group. The cystatin C level in the cerebrospinal fluid of all the four groups were tested. Then the results were compared and studied. Results After the study and comparison,we found that the cystatin C level in the cerebrospinal fluid of the D group was lower than that of the other three groups（P 〈0.01 ）. The cystatinC level in the cerebrospinal fluid of the C group was especially higher than that of A group and B group（ P 〈 0.05 ）. But the levels of A group and B group had no difference（ P 〉 0. 05 ）. Conclusion The cystatin C level in the cerebrospinal fluid of the patients with lumbar disc herniation were higher than that of healthy person, the level of the lumbar herniated disk patients was especially higher, and it is worthy of further studying.