表皮葡萄球菌的临床分布及耐药性分析

Clinical distribution and antibiotic resistance of S. epidermidis

目的，解表皮葡萄球菌（SE）临床感染分布及耐药情况。方法对本文分离的121株sE的感染分布和耐药性进行统计分析。结果临床感染的121株sE中有46株（38．0％）来自泌尿感染，37株（30．6％）来自上呼吸道感染，其次是创伤分泌物23株（19．0％）等。检出耐甲氧西林表皮葡萄球菌（MRSE）97株（80．2％）。药敏结果显示：sE对临床常用抗生素有不同程度的耐药，而且是多重耐药。MRSE对β-内酰胺类抗生素、氨基糖苷类（阿米膏星、庆大霉索）、喹诺酮类（氧氟沙星、环丙沙星）、红霉索、复方新诺明有较高的耐药性（〉46％）。MRSE对头孢唑林和阿米卡星较敏感。未发现对万占霉素耐药的菌株。结论SE可引起多部位感染，以泌尿系感染和上呼吸道感染为主，SE对临床常用抗生素有较高的耐药性，应引起临床和实验室人员的重视。

Objective To investigate the clinical distribution and drug - resistance of S. epidermidis（SE）. Methods Making a statistic analysis tor distribution of SE infection and resistance to 11 antibiotics. Results Fourty - six（38.0% ） among 121 clinical isolates come from urinary tract infection, thirty - seven （30.6%） come from uppor respiratory tract infec- tion,and another twenty- three （19.0% ） come from wound secretion, et al. Meticillin -resistant SE （MRSE） rated with 80.2% （97/121）. The result of drug susceptibility showed. The SE resisted to commonly antibiotics at different degrees, and multi - resistance. The drug - resistant rate of MRSE to the 13 - lectamase antibiotics, aminoglycosides （ amikacin, gentamicin） , fluoroquinolones（ofloxacin,ciprofloxacix） ,erythromycin and compound sulfamethoxazole was all over 46%. MSSE had a higher susceptibility to cefazolin and amikacin. There was no drug - resistant SE strain to vancomycin bging found. Conclusion SE mainly from urinary tract infection, and upper respiratory tract infection. It can cause infection in many other sites, it is highly resistant to used muhi - antibiotics. Attention should be taken by the clinical and laboratory staff.