摘要
目的观察吉西他滨治疗老年肺癌的疗效及毒性反应。方法60例老年晚期非小细胞肺癌患者同期分为治疗组与对照组。治疗组30例采用吉西他滨1000mg/m^2,第1、8、15天静脉滴注,每28d为一周期,共2周期。对照组30例采用中药艾迪注射液每日40~60ml连续15d静脉滴注。结果治疗组30例非小细胞肺癌有效率为26.7%,对照组30例非小细胞肺癌有效率为6.7%,两组比校,有显著性差异(P〈0.05)。KPS评分治疗组有效率为73.3%,对照组为36.7%,治疗组的KPS评分明显提高,有显著性差异(P〈0.05)。毒副反应治疗组血小板下降Ⅱ~Ⅲ度53.3%,白细胞下降Ⅱ~Ⅲ度33.3%,均无Ⅳ度发生;恶心呕吐,Ⅱ~Ⅲ度占23.3%,程度较轻,与对照组比较有明显差异(P〈0.05)。其他副反应轻微。结论吉西他滨单药治疗老年非小细胞肺癌疗效确切,毒副反应可以耐受,可作为常用治疗方案之一。
Objective To observe efficacy and toxicity of the Gemcitabine in treatment of advanced non - small cell lung cancer in the elderly. Methods 60 elderly patients with advanced non - small cell lung cancer over the same period were divided into treatment group and control group. In group, 30 patients treated with gemcitabine 1000 mg/m^2 , ivgtt, d1,8, 15, every 28 days for a cycle, a total of 2 cycles. In control group, 30 cases treated with traditional Chinese medicine Aidi injection, 40 -60 ml a day for 15 days. Results Treatment group, 30 patients with non - small cell lung cancer rate was 26. 7% in the control group of 30 patients with non - small cell lung cancer rate was 6. 7%, compared with school groups (P 〈0. 05), there were significant differences. KPS score the treatment group was 73.3%, 36.7% in the control group, treatment group KPS score was significantly increased( P 〈 0. 05 ), significant difference. Toxicity of the treatment group decreased platelet Ⅱ~Ⅲ degree 53.3%, WBC Ⅱ~Ⅲ fdegree 33.3%, no grade Ⅳ occurred; nausea and vomiting, Ⅱ~Ⅲ degree accounted for 23.3 %, to a lesser extent, compared with the control group significantly difference ( P 〈 0. 05 ). Other minor side effects. Conclusion Gemcitabine in treatment of elderly non - small cell lung cancer is effective and toxicity can be tolerated. It can be one of the commonly used treatment options for elderly patients with advanced non - small cell lung cancer.
出处
《中国医学创新》
CAS
2010年第8期30-32,共3页
Medical Innovation of China
关键词
老年非小细胞肺癌
化疗
吉西他滨
艾迪注射液
Elderly non -small cell lung cancer
Chemotherapy
Gemcitabine
Aidi injection