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Hepcidin的研究进展 被引量：5

Research Progress on Hepcidin
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摘要 介绍了Hepcidin的分子结构特点,从Hepcidin与机体铁稳态、炎症与感染、贫血和缺氧的关系角度,探讨了Hepcidin的研究进展。 The characteristics of molecular structure of Hepcidin were introduced.The research progress of Hepcidin was discussed from the perspectives of the relationships between Hepcidin and iron homeostasis of organism,inflammation,infection,anemia,oxygen-poor.
作者 党晓伟 李梦云 常娟 尹清强 左瑞雨 王平 王朋朋
机构地区 河南农业大学牧医工程学院 郑州牧业工程高等专科学校畜牧工程系
出处 《安徽农业科学》 CAS 北大核心 2010年第7期3351-3353,共3页 Journal of Anhui Agricultural Sciences
基金 河南省教育厅项目(2009B230012)
关键词 HEPCIDIN 抗菌肽 铁代谢 炎症 贫血 Hepcidin Antibacterial peptide Iron metabolism Inflammation Anemia
分类号 Q789 [生物学—分子生物学]
  • 相关文献

参考文献14

  • 1KRAUSE A,NEITZ S,MAGERT H J,et al. LEAP-1 ,a novel highly disulfide-bonded human peptide,exhibits antimicrobial activity[J]. FEBS Lett, 2000,480:147 -150.
  • 2NICOLAS G,BENNOUN M ,PORTEU A,et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin [ J ]. Proc Natl Acad Sci USA ,2002,99:4596 - 4601.
  • 3PARK C H,VALORE E V,WARING A J,et al. Hepcidin,a urinary antimicrobial peptide synthesized in the liver[J]. Biol Chem,2001,2q6:7806 - 7810.
  • 4PIGEON C, ILYIN G, COURSELAUD B, et al. A new mouse liver-specific gene,encoding a protein homologous to human antimicrobial peptide hepcidin,is overexpressed during iron overload [ J ]. J Biol Chem ,2001,276:7811 -7819.
  • 5NICOLAS G, BENNOUN M, DEVAUX I, et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice [ J ]. Proc Nail Acad Sci USA ,2001,98 ( 15 ) :8780 - 8785.
  • 6GANZ T. Hepcidin,a key regulator of iron metabolism and mediator of anemia of inflammation [ J ]. Blood ,2003,102:783 - 788.
  • 7FLEMING R E, SLY W S. Hepcidin:a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease [J]. Proc Natl Acad Sci,2001,98(15) :8160-8162.
  • 8FRAZER D M,WILKINS S J,BECKER E M,et al. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats [ J ]. Gastroenterology,2002,123:835 - 844.
  • 9SHIKE H,LAUTH X,WESTERMAN M E,et al. Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge[J]. Eur J Biochem, 2002,269:2232 - 2237.
  • 10NICOLAS G,CHAUVET C, VIATTE L,et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia and inflammation[J]. J Clin Invest,2002,110(7) :1037 - 1044.

二级参考文献22

  • 1Krause A et al. FEBS Lett, 2000, 480(3): 147-150.
  • 2Park CH et al. J Biol Chem, 2001, 276(11): 7806-7810.
  • 3Shike H et al. Eur J Biochem, 2002, 269(8): 2232-2237.
  • 4Pigeon C et al. J Biol Chem, 2001, 276(11): 7811-7819.
  • 5Hunter HN et al. J Biol Chem, 2002, 277(40): 37597-37603.
  • 6Ilyin G et al. FEBS Lett, 2003, 542(1-3): 22-26.
  • 7Nicolas G et al. Proc Natl Acad Sci USA, 2002, 99(7): 4596-4601.
  • 8Kulaksiz H et al. Gut, 2004, 53(5): 735-743.
  • 9Ludwiezek S et al. J Mol Med, 2004, 82(6): 373-382.
  • 10Deicher R et al. Nephrol Dial Transplant. 2004. 19:521-524.

共引文献1

同被引文献80

引证文献5

二级引证文献9

安徽农业科学
2010年 第7期

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