甲硝唑根管消毒控释系统的制备及药效研究

THE PREPARATION AND THE DRUG EFFECTIVE STUDY OF THE CONTROLLED RELEASE DELIVERY SYSTEM CONTAINING METRONIDAZOLE FOR ROOT CANAL DISINFECTION

利用渗透泵原理，以牙胶尖为载体研制了贮库型甲哨唑根管消毒控释系统（ＣＲＤＳＭ）。体外释药试验表明，２４ｈ能释出该装置全部药量２．０１３ｎｇ的６８．２４％；离体牙根周释药试验表明，ＣＲＤＳＭ持续释放有效药物浓度在１０ｄ以上，体内抑菌试验表明，抑菌作用稳定、持久。

In the light of osmotic pump theory, using gutta percha as carrier, the controlled release delivery system containing metronidazole(CRDSM) for root canal disinfection was developed. The experiments in vitro showed that this system contained metronidazole 2.013 ng and released 68.24% of the total in 24h; the experiments done on healthy single root canal teeth showed that the effective metronidazole concentration in vivo released from CRDSM lasted more than 10 days. Its antibacterial effect in vivo,contrasted to the formocresol group, was more constant and lasted more time. CRDSM can carry the drug and controll the release rate.