奥美拉唑致精神异常

Mental disorders due to omeprazole

1例86岁男性再生障碍性贫血患者,因上消化道出血给予奥美拉唑80 mg/d静脉泵入。用药第8天患者出现烦躁不安、多语、易怒、失去自控力、拒食、自行拔出胃管,并有幻觉、错觉,且拒绝全部治疗。用药第10天停用奥美拉唑,3 d后精神症状逐渐缓解。再次泵入该药再次出现上述精神症状,停药后症状消失。

A 86-year-old man with aplastic anemia received omeprazole 80 mg/d via an IV pump for control of upper gastrointestinal hemorrhage.On day 8 of therapy,the patient developed agitation,hyperphasia,irritability,loss of self-control,refusal to eat,pulling out a stomach tube on his own,hallucination and illusion,and refusal of all therapy.On day 10 of therapy,omeprazole was stopped.Three days later,his mental symptoms relieved gradually.The above-mentioned symptoms recurred after readministration of omeprazole via an IV pump and subsided after the drug discontinuation.