摘要
1例65岁男性肺癌患者,因不能耐受多种化疗药物遂给予吉非替尼250 mg,1次/d。2 d后患者出现胸闷、气促,双肺可闻及哮鸣音。实验室检查:血SpO20.60,PO263 mm Hg,PCO245 mm Hg,ALT 445U/L,AST 383U/L,LDH 2 277U/L,HBDH968U/L。肺CT示双肺间质纤维化伴感染。停用吉非替尼,同时静脉推注甲泼尼龙、盐酸氨溴索及奥美拉唑,病情无改善,因多器官功能衰竭抢救无效死亡。
A 65-year-old man with lung cancer received gefitinib 250 mg once daily due to poor tolerance to several chemotherapeutic drugs.Two days later,the patient presented with chest distress,short of breath,and wheezing was heard in both lungs.His oxygen saturation was 0.60.Laboratory tests revealed the following levels and values： PO2 63 mm Hg,PCO2 45 mm Hg,ALT 445 U/L,AST 383 U/L,LDH 2 277 U/L,HBDH 968 U/L.A pulmonary CT scan showed bilateral pulmonary interstitial fibrosis with infections.Gefitinib was withdrawn.He was treated with an IV push of methylprednisolone,ambroxol hydrochloride,and omeprazole.His symptoms did not resolve.The resuscitation was unsuccessful and he died from multiple organ failure.
出处
《药物不良反应杂志》
2009年第6期429-430,共2页
Adverse Drug Reactions Journal
关键词
吉非替尼
不良反应
肺间质纤维化
肝损害
gefitintib
adverse reactions
pulmonary interstitial fibrosis
liver damage
