摘要
2例高血压病患者使用硝苯地平致牙龈增生。例1,43岁男性患者口服硝苯地平10 mg,2次/d。用药5年后患者出现牙龈乳头增大伴有龈缘充血。停用硝苯地平,改为坎地沙坦酯。1个月后症状好转。例2,78岁女性患者因血压控制不佳给予硝苯地平30 mg,1次/d。用药1年后患者出现牙龈乳头增大伴有轻度充血。停用硝苯地平,改为氨氯地平。2周后症状缓解。
Two patients with hypertension developed gingival hyperplasia after administration of nifedipine.Patient 1,a 43-year-old man,recevied nifedipine 10 mg twice daily.After 5 years of therapy,the patient developed of gingival papilla enlargement accompanied by hyperemia of gingival margin.Nifedipine was withdrawn and changed to candesartan cilexetil.One months later,his symptoms improved.Patient 2,a 78-year-old woman,was treated with nifedipine 30 mg once daily due to poor control of hypertension.After one year of the therapy,the patient experienced of gingival papilla enlargement with mild hyperemia.Nifedipine was discontinued and switched to amlodipine.Two weeks later,her symptoms relieved.
出处
《药物不良反应杂志》
2009年第6期436-438,共3页
Adverse Drug Reactions Journal
关键词
硝苯地平
不良反应
牙龈增生
nifedipine
adverse reactions
gingival hyperplasia
