原发性肝癌介入治疗中化疗栓塞模式的探索

Study of Therapeutic Modality of Transcatheter Hepatic Arterial Infusion Chemotherapy and Embolization in Hepatocellular Carcinoma

为探讨空气作为栓塞剂在原发性肝癌介入治疗中的应用并作出评价。选择13例不能切除的原发性肝癌经肝动脉灌注化疗后用空气20～30ml栓塞，2～3周一次，反复治疗2～4次，疗程末用碘油阿霉素乳剂作最后栓塞。治疗中观察血象、肝功能、AFP和肿瘤大小的变化，并作长期随访。结果：治疗后肿瘤缩小50％以上者3例，不足50％者9例，变化不明显者1例。随访结果6例生存不足6月，3例生存10月，2例12月，另2例生存超过3年未见复发。结论：以空气作为栓塞剂的化疗栓塞是一种有效的治疗模式。

To evaluate the effect of air embolus in transcatheter arterial infusion chomoembolization ofprimary hepatocellular carcinoma . Materials and Methods: Thirteen patients with unresectable hepatocellular carcinoma were treated with transcatheter hepatic arterial infusion chemotherapy and then embolized by air 20 to 30 ml , once every 2 to 3weeks , total 2 to 4 times . At the end of course , the mixture of ADMand lipiodol were used to embolize the hepatic artery . During the couase of treatment , the hemogram , hepaticfunction ,AFP levels were checked up and the variation of tumor size was monitored . All patients were followedup . Results : The size of tumor retracted more than 50%in 3 of 13 cases. Nine cases retracted less than than 50% and one did not chang. Six cases survived less than 6 months , three cases survived for 10 months and 2 cases for one year , another 2 patients have survived for more than 3 years without recunence . Conclusion : It is an effective method to embolize the hepatic artery by air embolus after the infution chemotherapy.