几种中药提取液对小鼠明暗箱行为干预的评价

EFFECTS OF SEVERAL HERBAL EXTRACTS ON ANXIETY BEHAVIOR OF MICE

目的通过对小鼠明暗箱实验行为的影响，探讨几种中药提取液的抗焦虑效果。方法雄性昆明种小鼠49只随机分成5组：天麻组（10只）、熟地黄组（10只）、羊栖菜组（9只）分别连续灌胃7d。地西泮组（11只）前3d灌胃生理盐水，后4d灌胃地西泮。生理盐水组（9只）连续灌胃7d等容积的生理盐水（1m1）。7d后开始进行小鼠明暗箱行为检测。

Objective To select effective anti-anxiety herb by combined open field test for building up Chinese medicine compound in the future. Methods 49 male kunming mice were randomly classified as 5 groups： Gastrodia elata group（10 mice）, Prepared rehmannia root group （10 mice）, Sargassum fusiforme group （9 mice）, and these groups were continually administered drugs by ig. for 7 days. Dizapam group （11 mice） was administered sodium chloride solution for the previous 3 days, then was administered dizapam for the next 4 days.