白介素-6和肿瘤坏死因子在不同类型冠心病中的作用探讨

Effects of IL-6 ,TNF-α in Patients with different kinds of coronary heart disease

目的探讨白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）在不同类型冠心病（CHD）中的作用及临床意义。方法选择急性心肌梗死（AMI）患者30例、不稳定型心绞痛（UAP）患者30例、稳定型心绞痛（SAP）患者25例、对照组非冠心病患者20例为研究对象，分别检测血清IL-6、TNF．仪水平并进行比较。结果AMI组、UAP组的血清IL-6、TNF-α水平与SAP组和对照组比较，差异均有统计学意义（P〈0．01）；AMI组的血清TNF-α、IL-6水平与UAP组比较，差异有统计学意义（P〈0．05）。结论IL-6介导的炎性反应可能参与动脉粥样斑块的易损和破裂；TNF-d在促进动脉粥样硬化（AS）形成及斑块不稳定方面可能起重要作用。

Objective To investigate the effects of IL-6,TNF-α in patients with different kinds of coronary heart disease（CHD） and their clinical significance. Methods Totally 30 patients with acute myocardial infarction （AMI） , 30 cases with unstable angina pectoris （UAP）and 25 cases with stable angina pectoris （SAP）were enrolled as the subjects, with 20 subjects with no coronary heart disease as controls. The serum concentrations of IL-6 and TNF-α were measured, and the results were analyzed and compared. Results Compared with SAP group and control group, the serum concentrations of IL-6 and TNF-α in AMI group and UAP group were significantly increased（ P 〈 0. 01 ）. Compared with UAP group,the serum concentrations of IL-6 and TNF-ot in AMI group were statistically higher（ P 〈 0. 05 ）. Conclusion The inflammatory reaction induced by IL-6 may take part in the vulnerability and rupture of ath- eromatous plaque ; TNF-α may play an important role in promotion of AS development and instability of plaque.