儿童过敏性紫癜血管内皮生长因子血浆含量变化

The change of plasm level of vascular endothelial growth factor in children anaphylactoid purpura

目的探讨血管内皮生长因子（VEGF）血管含量变化与儿童过敏性紫癜（AP）的关系。方法选择已确诊的急性期紫癜性肾炎（APN）组和无肾损害的AP组各24例，于同时间、同群体中选择健康儿童24名为对照组。采用ELISA法分别检测三组血浆VEGF含量并分析。结果APN组、AP组和对照组VEGF血浆含量分别是（244．56±51．12）μg/L、（155．714-50．48）μg/L和（54．91±40．07）μg/L，经比较，差异有统计学意义（F=95．789，P=0．000〈0．01）。APN组和AP组均高于对照组，APN组亦高于AP组，差异有统计学意义。结论儿童AP急性期血浆VEGF含量增高，APN比无肾损害的AP更高，说明了VEGF参与了AP血管炎的发生发展过程，并可反映其病情程度。

Objective To explore the relationship between plasm level of vascular endothelial growth factor （VEGF） and children Anaphylactoid purpura（AP）. Methods The concentrations of VEGF in serum were detected with enzyme-linked immunosorbent assay in twenty four children with AP, twenty four children with APN in acute phase and twenty four healthy children. Results The concentrations of VEGF in patients with APN in acute phase, AP and normal control was （244.56 ± 51.12 ） μg,/L, （ 155.71 ± 50.48 ） μg/L and （54. 91 ± 40. 07 ） μg/L, respectively. Plasma levels of VEGF in children with APN and AP were significantly higher than those in normal control, statisti- cally significant difference was observed （ F = 95. 789,P = 0. 000 〈 0. 01 ）. Conclusion The concentrations of VEGF in serum increases markedly in acute phase of AP, those in APN is higher than in AP. It indicated that VEGF involved in the occurrence and development of AP vasculitis, and may reflect the extent of pathogenetic condition.