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心血管系统中微小RNA的作用 被引量：2

Implication of MicroRNAs in the Cardiovascular System
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摘要 miRNA是一类内源性的,小的非编码的RNA,它可以调节人类大约30%的蛋白质编码基因。到目前为止,已有400多个人的miRNA被克隆和测序,其中一些miRNA在心血管组织高表达和特异性表达,参与心脏发育、心肌肥大/心力衰竭、电重塑和血管增殖的调节,miRNA在心血管方面的生理和病理意义越来越被关注,将来也很有希望为心血管疾病的治疗提供新的手段。 MicroRNAs（miRNAs）are endogenous,small,noncoding RNAs that can regulate about 30% of the human protein-coding genes.So far,more than 400 miRNAs have been cloned and sequenced in human and some of them are highly and specifically expressed in cardiovascular tissues.These miRNAs are involved in the regulation of heart development,cardiac hypertrophy/heart failure,electrical remodeling and vascular proliferation.Physiopathological implications of miRNA in the cardiovascular system have been increasingly concerned,which may provide new means of cardiovascular diseases treatment in the future.
作者 秦升 金百翰 魏茜 任安经
机构地区 第二军医大学研究生管理大队 第二军医大学基础部病理生理学教研室
出处 《医学综述》 2010年第5期644-646,共3页 Medical Recapitulate
基金 国家自然科学基金(30800375) 第二军医大学本科生创新基金(MS2008024)
关键词 心血管 心肌肥大 血管增生 微小RNA Cardiovascular Cardiac hypertrophy Vasculoproliferation miRNA
分类号 Q52 [生物学—生物化学] R541 [医药卫生—心血管疾病]
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参考文献28

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同被引文献19

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医学综述
2010年 第5期

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