摘要
人类肥胖者大多存在高瘦素血症和瘦素抵抗。目前,瘦素抵抗作为肥胖发生的一个重要危险因素已经得到公认,但具体清晰的作用机制仍未阐明,仅有瘦素受体突变、瘦素转运、瘦素信号抑制、血管内缺陷、转换缺陷等各种假说。全球的研究者正试图以这些假说为基础探讨肥胖的发生机制,进而攻克肥胖。该文对有关文献进行整理并总结了瘦素抵抗机制可能通路,以期对肥胖的瘦素抵抗机制研究有一定的参考意义。
Most of the obese humans are hyperleptinemia,which means that leptin resistance wass widespread.Currently,the theory that leptin resistance was a primary risk factor for obesity has been accepted widely.But the clear mechanism had not been discovered.The occurrence of leptin resistance may be related to leptin receptor mutation,leptin transhipment,leptin signal suppression,vascular defects,defects such as conversion.The researchers from all over the world were trying to discover the mechanism based on these theory and are expecting to cure the obesity through their.In this paper,the researches in this area in recent years were reviewed.And the access of leptin resistance was summed up.Maybe this work will have certain reference value of mechanism of leptin resistance in obesity research.
出处
《医学综述》
2010年第5期662-665,共4页
Medical Recapitulate
关键词
肥胖
瘦素抵抗
机制
Obesity
Leptin resistanc
Mechanism
