黄芪对48例慢性阻塞性肺疾病患者肺功能及免疫功能的影响

Influence of Astragalus Injection on Pulmonary Function and Immune Function in Chronic Obstructive Pulmonary Disease

目的探讨在常规治疗的基础上辅以黄芪注射液治疗COPD的临床疗效,以及进一步探讨对COPD患者肺功能及免疫功能的影响。方法96例COPD患者随机分为治疗组和对照组各48例,对照组采用抗感染、吸氧、平喘等常规治疗。治疗组在常规治疗的基础上辅以黄芪注射液。观察两组治疗的临床疗效,及两组治疗前后肺功能的改善及免疫功能的变化(主要为T淋巴细胞亚群的变化)。结果治疗组的显效率为91.67%,对照组显效率为79.17%,两组比较差异有显著性(P<0.05)。治疗组治疗后肺功能改善明显,与治疗前比,P<0.01,与对照组比较,P<0.05。治疗组治疗后的免疫功能主要表现为CD3、CD4、CD4/CD8升高,CD8下降。观察组住院天数小于对照组,差异有显著性(P<0.05)。结论常规治疗的基础上加用黄芪注射液治疗COPD,可明显改善患者的肺功能及提高T淋巴细胞的免疫功能,无明显副作用,可广泛应用于临床。

Objective To investigate the clinical efficacy of astragalus injection in the treatment of chronic obstructive pulmonary disease （COPD） on the basis of the routine treatment and further to explore its effect on pulmonary function and immune function. Methods Ninety-six cases of COPD were randomly divided into treatment group and control group with 48 cases for each group. Both groups were given the routine treatment including antibiotics,infection control,oxygen uptake,antiasthmatie drugs, etc, and the astragalus injection was added to the treatment group. The clinical efficacy as well as the improvement of lung function and the changes in the immune function （mainly T-lymphocyte subset change） before and after treatment in the two groups were observed. Results The efficiency of the treatment group was 91.67% and that of the control group was 79.17%,with a significant difference between the two groups（P〈0.05）. The lung function was significantly improved in the treatment group after treatment compared with that before treatment（P〈0.01 ） and with that of the control group（P〈0.05）. The control group showed no significant change in the immune function before and after treatment. CD3,CD4 and CD4.CD8 were increased in the treatment group after treatment,and CD8 was decreased. There was a significant difference in the days of hospital stay in the treatment group compared with the control group（P〈O.05）. Conclusion The conventional treatment supplemented with astragalus for COPD can improve the lung function and enhance the tlymphocyte immune function,with no obvious side effects,which can be widely used.