夫精宫腔内人工授精患者性激素变化的分析

Analysis of The Change of Sex Hormones of the Patients Undergone Intra Uterine Insemination

目的探讨接受夫精人工授精治疗患者(IUI)在夫精人工授精周期中性激素浓度的变化,分析人工授精技术本身是否影响患者性激素浓度差值的变化,进而分析激素水平变化是否影响夫精人工授精的成功率。方法对50例夫精人工授精患者进行激素水平检测,并以同期就诊于本科室门诊的促排卵或自然周期指导同房的不孕患者作为对照组比较两组患者月经第二天及HCG注射日睾酮(T)、垂体泌乳素(PRL)、促甲状腺激素(TSH)的浓度,计算T、PRL和TSH在HCG注射日与月经第二天的浓度差值。结果①IUI组与对照组患者性激素浓度变化经比较,两组患者的泌乳素、睾酮和促甲状腺激素浓度的差值在统计学上无显著性差异(t=0.68～0.86,P>0.05)。②行IUI治疗的患者中,妊娠组与非妊娠组的性激素浓度变化在统计学上无显著性差异(P>0.05)。结论①夫精人工授精技术的实施不会影响不孕症患者性激素浓度的差值变化。②夫精人工授精患者性激素浓度差值的变化对人工授精成功率影响不大,应提高人工授精技术水平,以期提高人工授精的成功率。

Objective To study the change of sex hormones of the infertility patients undergone intra uterine insemination （IUI）, analyzed the effects of the change of sex hormones by the technique of the IUI,and the changed of sex hormones levels to the success of IUI. Methods 50 infertility women undergone Intra Uterine Insemination and 40 infertihty women （married）who visited our centre as control,the levels of testosterone（T）,prolactin （PRL）, thyroid stimulating hormone （TSH）were examined on second day of the menstrual cycle and the day of human chorionic gonadotropin （HCG）,calculated the changes of sex hormones. Results There was no significant difference to the levels of prolactin （PRL）, testosterone （ T ）, thyroid stimulating hormone （TSH） （P 〉 0.05 ）. The patients of undergone inca uterine insemination （IUI）, there was no significant difference to the pregnant and unpregnant with the changes of sex hormones（P〉0.05 ）. Conclusion The technique of the IUI has no effects to the changed of sex hormones levels on the patients. There has little effects to the success of IUI on the change of sex hormones. We should improve the technique of the IUI in order to increase the clinical pregnancy rate.