旅英华人与当地白人血管内皮功能的对比性研究

Vascular Endothelial Function Differences Between UK Chinese and UK Caucasians

目的研究旅英华人和当地白人血管内皮功能有无差异。方法选取年龄、性别相似的旅英华人和当地白人各40名(男女各20名),检测体质量、身高、腰围、血压、血脂、血糖、血流介导的内皮依赖性血管舒张功能(FMD)等,比较两组检测结果,并分析心血管危险因素、种族与FMD的相关性。结果旅英华人的舒张压、FMD较当地白人高[舒张压(80.2±9.1)比(75.1±11.3)mmHg;FMD(6.76±2.95)%比(5.52±2.13)%,均P<0.05],体质量、腰围、体质量指数(BMI)较当地白人低[体质量(65.4±10.9)比(74.3±12.4)kg;腰围(82.2±8.1)比(89.4±10.9)cm;BMI(23.5±2.3)比(24.8±3.2)kg/m2;均P<0.05]。旅英华人饮食以中餐为主,占80%,白人则全以西餐为主。种族因素、饮食习惯与FMD相关(偏回归系数分别为-1.232、1.555,均P<0.05)。结论旅英华人的血管内皮功能优于当地白人,可能与种族因素、饮食习惯相关。

Objective To compare the vascular endothelial function between UK Chinese and UK Caucasians.Methods Forty UK Chinese and 40 age-and sex-matched UK Caucasians were enrolled.The anthropometry,blood pressure,serum lipid profile and glucose and flow mediated dilation （FMD） by ultrasound method were measured.Results Diastolic blood pressure （DBP） and FMD of UK Chinese were higher than those of UK Caucasians [DBP （80.2±9.1） vs （75.1±11.3）mmHg;FMD （6.76±2.95）% vs （5.52±2.13）%,both P〈0.05],while weight,waist circumference,body mass index（BMI） of UK Chinese were lower than those of UK Caucasians [weight （65.4±10.9） vs （74.3±12.4） kg;waist circumference （82.2±8.1） vs （89.4±10.9） cm;BMI （23.5±2.3） vs （24.8±3.2） kg/m^2;all P〈0.05].Western-style food accounted for 20% in diet of the UK Chinese and 100% in diet of the Caucasians.Ethnicity and diet habit were correlated with FMD （B=-1.232,1.555,both P〈0.05）.Conclusion The vascular endothelial function of UK Chinese appears to be superior to that of UK Caucasians,which may be associated with the ethnicity and dietary.