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聚异丙基丙烯酰胺及其衍生物在组织工程中的应用 被引量:2

Application of Poly(N-isopropylacrylamide) and Its Derivatives in Tissue Engineering
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摘要 聚异丙基丙烯酰胺(PNIPAAm)是一种新型的智能高分子材料。PNIPAAm大分子侧链上由于同时具有亲水性的酰胺基和疏水性的异丙基而具有良好的温敏性能,同时它还显现出良好的生物相容性和无细胞毒性等特性,可作为理想的细胞外基质材料应用于组织工程领域。本文综述国内外关于PNIPAAm及其衍生物在组织工程中的研究及应用情况。 Poly-N-isopropylacrylamide(PNIPAAm) is a new kind of intelligent material.It shows favorable thermo sensitivity because of the structure of hydrophilic acrylamino and hydrophobic isopropyl.PNIPAAm also shows good biocompatibility and non-toxicity.All the characters as above make it an ideal extra cellular matrix material for tissue engineering.This paper reviews its application in tissue engineering.
出处 《生物医学工程学杂志》 EI CAS CSCD 北大核心 2010年第1期206-210,共5页 Journal of Biomedical Engineering
基金 广东省科技项目资助(2006B35802003)
关键词 聚异丙基丙烯酰胺 温度敏感 组织工程 细胞支架 可注射凝胶 Poly-N-isopropylacrylamide(PNIPAAm) Thermo sensitivity Tissue engineering Scaffold Injectable hydrogel
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