血尿酸水平与氧化应激在急性脑梗死发生中的关系探讨

Relationship between the level of serum uric acid and oxidative stress in the occurrence of acute cerebral infarction

目的通过了解急性脑梗死(cerebral infarction,CI)患者血清尿酸(uric acid,UA)水平、氧化应激损伤程度及其相互联系,探讨血尿酸升高及氧化应激损伤在60岁以上老年人急性脑梗死发生中的作用。方法随机选择60例急性脑梗死患者(≥60岁)作为脑梗死组和30例健康人为对照组,测定外周血清UA、8-异前列腺素F2a(8-iso prostaglandin F2a,8-iso PGF2a)水平和总超氧化物歧化酶(total superoxide dis-mutase,T-SOD)活力。结果脑梗死组血清UA、8-iso PGF2a水平均高于对照组(P<0.01),而T-SOD明显低于对照组(P<0.01)。血清UA和8-iso PGF2a之间呈正相关(r=0.698,P<0.01),UA和T-SOD活力呈负相关(r=-0.712,P<0.01)。8-iso PGF2a与T-SOD活力也呈负相关(r=-0.723,P<0.01)。脑梗死组高尿酸血症与正常血尿酸者相比,血浆8-iso PGF2a水平明显增高、T-SOD活力明显降低(P<0.01)。结论血清UA水平升高可能是CI的一个危险因素,其可能通过促进氧化应激损伤增加,抗氧化能力降低,导致了CI的发生发展。

Objective To elucidate the effects of elevated serum uric acid（UA） level as well as oxidative stress damage on acute cerebral infarction（CI） by exploring the level of serum UA and oxidative stress damage in the more than 60 years old patients with acute cerebral infarction.Methods The levels of serum UA,8-isoprostan prostaglandin F2a（8-iso-PGF2a） and total superoxide dismutase（T-SOD） activity were measured in 60 patients with acute cerebral infarction and 30 cases of healthy people.Results Compared with the healthy controls,the levels of UA、8-iso-PGF2a were higher in Acute Cerebral Infarction（P〈0.01）.T-SOD was significantly lower than the healthy control group（P〈0.01）.The serum UA level was positively correlated with 8-iso-PGF2a（r=0.698,P〈0.01）,but the serum UA level was negatively correlated with T-SOD activity（r=-0.723,P〈0.01）.8-isoPGF2a also was negative correlation with T-SOD activity（r=-0.723,P〈0.01）.Compared with normal serum uric acid in cerebral infarction group the plasma levels of 8-isoPGF2a significantly increased,T-SOD obviously decreased in cerebral infarction group with hyperuricemia（P〈0.01）.Conclusions Serum UA level may be a risk factor of CI,and induces the pathogenesis and development of CI by promoting the oxidative stress damage and decreasing the ability of anti-oxidation.