摘要
合成并制备了支链淀粉-三(苯基氨基甲酸酯)手性固定相,利用高效液相色谱首次拆分了酸性外消旋药物联苯双酯,考察了流动相中异丙醇含量对拆分的影响。
Amylopectin_tris(phenylcarbamate) was synthesized and used as a chiral stationary phase after its adsorption on sillica gel. Four chiral biphenyl diesters of acidic drugs were resolved. The effect of isopropanol content on resolution has been studied.
出处
《分析测试学报》
CAS
CSCD
1998年第5期61-63,共3页
Journal of Instrumental Analysis
基金
中国科学院重点项目基金
关键词
HPLC
固定相
外消旋药物
拆分
联苯双酯
HPLC
Amylopectin_tris(phenylcarbamate)
Racemic acidic drugs
Enantiometric resolution