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心肌细胞兴奋-收缩耦联过程中钙离子调控的研究进展 被引量：2

Progress in Research of Ca^(2+) Signaling of Excitation-contraction Coupling in Cardiac Myocytes
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摘要 Ca2+作为细胞内重要的信使在心肌细胞兴奋-收缩耦联过程中起到重要作用,我们将钙离子对心肌细胞兴奋-收缩耦联过程的调控分为三个阶段:上游调控(胞浆中Ca2+升高),中枢调控(Ca2+与肌钙蛋白C结合),下游调控(粗细肌丝结合,形成横桥循环)。本文将对近几年发现的Ca2+在兴奋-收缩耦联过程中的调控作用进行介绍。 Cardiac calcium signal plays an important role in excitation-contraction coupling.The E-C coupling process can be classi？ed into three processes：upstream mechanism （Ca^2＋ mobilization）,central mechanism （Ca^2＋ binding to troponin C）,and downstream mechanism （Combination of thick and thin filaments,leading to crossbridge cycling）.This review focuses on the three processes and the role of Ca^2＋ in cardiac excitation-contraction （E-C） coupling in recent years.
作者 蔡云 杨长军 毛华 耿越
机构地区 山东师范大学生命科学学院
出处 《科技信息》 2009年第31期51-52,共2页 Science & Technology Information
关键词 CA2+ 兴奋-收缩耦联 心肌细胞 Calcium Excitation-contraction coupling Cardiac myocytes
分类号 Q463 [生物学—生理学]
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参考文献15

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同被引文献33

  • 1王泽剑,陈红专,薛庆生,陆阳.人参炔醇对大鼠原代培养的神经细胞过氧化氢损伤的影响[J].中草药,2005,36(1):72-75. 被引量：9
  • 2杜春娟,郭碧云,曾衍钧,徐小虎,于小军,赵虎.细胞受体外机械力作用的若干反响[J].医用生物力学,2005,20(2):118-122. 被引量：17
  • 3刘崇铭,王敏,满世伟.人参总皂甙与单体皂甙Re对动物心功能和血液动力学的影响[J].沈阳药科大学学报,1995,12(2):130-132. 被引量：8
  • 4李敬远,朱珊珊,曾因明.不同浓度人参皂甙对大鼠离体心脏缺血再灌注损伤的保护作用[J].中华麻醉学杂志,2005,25(8):618-620. 被引量：6
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  • 6Zorbas YG, Kakuris KK, Deogenov VA, et al. Inadequacy of calci- um supplements to normalize muscle calcium deficiency in healthy subjects during prolonged hypokinesia[J]. Nutrition,2008, 24(3):217-223.
  • 7Reay J L,Scholey A B,Kennedy D O.Panax ginseng(G115)improves aspects of working memory performance and subjective ratings of calmness in healthy young adults[J].Hum Psychopharmacol,2010,25(6):462-471.
  • 8Lee Y,Jin Y,Lim W,et al.A ginsenoside-Rh1,a component of ginseng saponin,activates estrogen receptor in human breast carcinoma MCF-7 cells[J].J Steroid Biochem Mol Biol,2003,84(4):463-468.
  • 9Hwang J W,Oh J H,Yoo H S,et al.Mountain ginseng extract exhibits anti-lung cancer activity by inhibiting the nuclear translocation of NF-kappa B[J].Am J Chin Med,2012,40(1):187-202.
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2009年 第31期

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