摘要
目的:建立复方白氟膜剂中盐酸麻黄碱和地塞米松磷酸钠的含量测定方法。方法:以XTerra RP18色谱柱为分离柱,以甲醇-0.34%KH2PO4溶液-三乙胺(52∶48∶0.2)为流动相,采用HPLC法测定。结果:该品中盐酸麻黄碱含量测定线性范围为8.032~80.32μg.mL-1(r=0.999 9),平均回收率为99.25%(RSD=1.10%,n=6);地塞米松磷酸钠含量测定线性范围为3.984~39.84μg.mL-1,平均回收率为98.10%(RSD=1.32%,n=6)。结论:此法操作简单、结果准确,可用于复方白氟膜剂的质量控制。
Objective:To develop an HPLC method for the determination of ephedrine hydrochloride and dexamethasone sodium phosphate in Compound Baifu Pellicles.Methods: Analysis was conducted on a XTerra RP_(18) radial compression column with a mobile phase of methanol-0.34%KH_2PO_4 solution-triethylamine(52∶48∶0.2).Results:The linear range of ephedrine hydrochloride was 8.032~80.32 μg·mL^(-1)(r=(0.999 9)),and the average recovery was 99.25%(RSD=1.10%,n=6);The linear range of dexamethasone sodium phosphate was 3.984~39.84 μg·mL^(1)(r=(0.999 9)),and the average recovery was 98.10%(RSD=1.32%,n=6).Conclusion:This method was simple and feasible for the quality control of Compound Baifu Pellicles.
出处
《中国实验方剂学杂志》
CAS
北大核心
2010年第3期29-31,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
广西壮族自治区科学技术青年基金资助项目(桂科青0229022)