2006～2008年医院感染临床病原菌分布及其耐药性调查分析

Distribution of Hospital Infections and Drug Resistance of Pathogenic Bacteria:Investigation and Analysis 2006-2008

目的了解2006～2008年医院感染临床病原菌谱及其耐药情况。方法对2006～2008年细菌室分离得到的938株临床病原菌进行统计及耐药分析。结果3年中革兰阴性杆菌检出构成比例逐年上升,革兰阳性球菌检出比例逐年降低;革兰阴性杆菌对氨苄西林/舒巴坦、哌拉西林、头孢噻吩、头孢呋辛、复方新诺明的3年平均耐药率>70.0%;革兰阳性球菌对复方新诺明、红霉素、氯霉素的3年平均耐药率>70.0%;产超广谱β-内酰胺酶(ESBLs)大肠埃希菌和肺炎克雷伯菌3年平均检出率分别为42.2%、37.1%;耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林表皮葡萄球菌(MRSE)3年平均检出率分别为85.5%、87.7%;金黄色葡萄球菌、表皮葡萄球菌对青霉素及苯唑西林平均耐药率>85.0%。结论2006～2008年医院检出临床病原菌耐药性不断增强,加强病原菌及其耐药率监测对指导临床合理用药至关重要。

OBJECTIVE To find out the hospital infection and drug resistance of pathogenic spectrum from 2006 to 2008.METHODS 938 strains of clinic pathogenic bacteria isolated by bacteriology laboratory and drug resistance from 2006 to 2008 were analyzed.RESULTS The constituent ratio of the detection in Gram-negative bacilli increased year by year in the last three years,while the detection in Gram-positive cocci decreased.The 3-year average rate of drug resistance of Gram-negative bacilli to ampicillin/sulbactam,piperacillin,cefalotin,cefuroxime,Cotrimoxazole was over 70%,and the 3-year average rate of drug resistance of Gram-positive cocci to Cotrimoxazole,erythromycin and chloramphenicol was over 70% also.The 3-year average detection rate of extended-spectrum β-lactamases（ESBLs） producing Escherichia coli and Klebsiella pneumoniae was 42.2% and 37.1%,respectively.The 3-year average detection rate of meticillin-resistant Staphylococcus aureus（MRSA） and meticillin-resistant S.epidermidis（MRSE） was 85.5% and 87.7%,respectively.The average drug resistance of S.aureus and S.epidermidis to penicillin and oxacillin was over 85%.CONCLUSIONS The drug resistance of clinic pathogenic bacteria in our hospital is boosting up from 2006 to 2008.It is of paramount importance to enhance the monitoring of pathogenic bacteria and their resistance to guide reasonable clinical medication.