医源性肺炎克雷伯菌感染及其耐药性分析

Klebsiella pneumoniae Isolated from Hospital-acquired Infection and Antimicrobial Resistance Analysis

目的掌握全院肺炎克雷伯菌引起的医源性感染状况及该菌的耐药特征。方法前瞻性调查分析2007～2009年医院发生医源性肺炎克雷伯菌感染情况。结果医源性肺炎克雷伯菌感染以下呼吸道为主,占76.4%;除对亚胺培南和哌拉西林/他唑巴坦高度敏感(100.0%)外,对其余17种抗菌药物均呈现不同程度的耐药。结论肺炎克雷伯菌已成为临床上引起医院感染的主要病原菌之一,且对抗菌药物的耐药性较为严重。

OBJECTIVE To investigate the situation and the antimicrobial resistance of Klebsiella pneumoniae isolated from hospital-acquired infection in our hosipital.METHODS We prospectively investigated and analyzed the discharged patients′ medical records from 2007 to 2009.RESULTS The lower respiratory tract infections had the highest rate among the hospital-acquired infections caused by K.pneumoniae,accounted for 76.4%.K.pneumoniae only showed high susceptibility to imipenem and piperacillin/tazobactam with 100% susceptible rate,but was resistant in differrent degree to seventeen other antibiotics.CONCLUSIONS K.pneumoniae has become one of the main pathogens of hospital-acquired infection,and its resistance is serious.