盐酸阿霉素脂质体与盐酸阿霉素在大鼠体内的组织分布

Tissue distribution of doxorubicin hydrochloric liposomes and doxorubicin hydrochloric in rats

目的:比较盐酸阿霉素脂质体与盐酸阿霉素在大鼠体内组织中的分布特征。方法:大鼠股静脉注射盐酸阿霉素及盐酸阿霉素脂质体注射液(0.8mg·100g-1体质量),采用HPLC法测定不同时间点大鼠组织脏器中的药物浓度。结果:与盐酸阿霉素相比,盐酸阿霉素脂质体在心脏组织中具有较低的浓度,而在肝脏及肾脏组织中的药物浓度高于阿霉素。结论:将阿霉素制成以脂质体载药,可在一定程度上降低心脏毒副作用,提高药物对肝脏和肾脏等肿瘤的治疗效果。

OBJECTIVE To study pharmacokinetic and distribution of doxorubicin HCl liposomes and doxorubicin HCl in rats. METHODS The solutions of doxorubicin HCl and doxorubicin HCl liposomes were administered to rats （0. 8 mg·100 g^-1 weigh） by femoral vein injection. The concentrations of doxorubicin in rat tissues were determined by high performance liquid chromatography. RESULTS The concentration of doxorubicin was lower in heart for liposomal compared to the unencapsulated formulation. On the other hand, the doxorubicin concentrations were higher in liver and kidney for liposomal compared to the unencapsulated formulation. CONCLUSION Doxorubicin liposomes might reduce cardiac side effects and enhance the drug concentration for the treatment of liver and kidney cancer.