苏丹红Ⅰ对小鼠血液和脏器系数的影响

Effect of Sudan Ⅰ on Blood and Organ Coefficients of Mice

研究苏丹红Ⅰ长期染毒对小鼠血常规和脏器系数的影响。将40只昆明雄性小鼠随机分成4组,3个染毒组分别给予含1000、500、250mg/kg苏丹红Ⅰ的饲料,对照组给予正常饲料,每10d测定1次体质量和血常规。60d后处死所有小鼠,计算脏器系数。结果显示,各染毒组小鼠出现不同程度的体质量增长缓慢现象;各染毒组小鼠的肝脏、脾脏和肾器系数在不同程度上均高于对照组;随小鼠染毒时间的增加,其血液中的红细胞和血红蛋白含量呈逐渐下降,白细胞和凝血时间呈逐渐增高的趋势,以1000mg/kg染毒组表现最为显著。结果表明,苏丹红I染毒后对小鼠的血细胞和实质脏器会造成一定程度的损伤。

In this study, the blood and organ coefficients of mice with long-term intake of Sudan Ⅰ were investigated. Totally 40 male Kunming mice were randomly divided into 4 groups, which were designated as control group fed normal diet and three groups fed diets containing Sudan Ⅰ at doses of 250, 500, 1000 mg/kg. Body weight （bw） determination and blood routine examination were conducted every 10 days. After 60 days, all mice were sacrificed and organ coefficients were calculated. Results indicated that slow body weight gain of the mice fed dietcontaining Sudan I was observed during the period of 60 days. The coefficients of liver/bw, spleen/bw and kidney/bw in the mice fed diet containing Sudan I were all obviously higher than those of the control mice. In addition, with increasing intake time of Sudan I, the number of red blood cells and the content of hemoglobin of mice exhibited a gradual decrease trend; In contrast, the number of white blood cells and clotting time exhibited an increase trend, especially for the mice in the group fed diet containing Sudan I at the dose of 1000 mg/kg. These investigations confirm that Sudan I can resulted in the damage of blood cells and organs.