子宫内膜异位症相关性疼痛与血管形成的关系

The correlation between the pelvic pain related to endometriosis and angiogenesis

目的:检测卵巢子宫内膜异位症(ovarian endometriosis,OEMs)周围血管形成,探讨子宫内膜异位症(endometriosis,EMs)相关性疼痛与血管形成的关系。方法:视觉模拟评分法(Visual analogue scale,VAS)按疼痛程度将患者分为A、B两组,A组病例无症状或者有轻微痛经,B组病例表现为中等及严重痛经或者有与经期相关的盆腔疼痛、坠胀。以多普勒超声和免疫组化法,分别检测两组囊肿周围血流分布及血流阻力指数(resistent index,RI)、搏动指数(pulsatility index,PI)和微血管密度(microvessel density,MVD),并对检测结果进行统计学分析。结果:两组囊肿周围血流分布、PI、RI、MVD均有显著性差异(P<0.05)。结论:子宫内膜异位症相关性疼痛与血管形成有关。

Objective：To explore whether a correlation exists between the pelvic pain,related to endometriosis and angiogenesis.Methods： the patients were divided into A,B groups according to the degree of pain.group A,asymptomatic patients or patients presenting mild dysmenorrheal;and group B,moderate/severe dysmenorrheal,we detected the amount of blood flow around the endometrial cysts,pulsatility and resistance indexes by Doppler ultrasound and microvessel density（MVD）.Results：Moderately or highly vascularized endometrial cysts were more frequent in group B（P 0.05）.The PI and RI were significantly lower in group B （P0.05）.The mean MVD was significantly higher in group B（P 0.05）.Conclusion： pelvic pain related to endometriosis is correlated with angiogenesis.