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Controlling intracellular Ca^(2+) spiral waves by the local agonist in the cell membrane

Controlling intracellular Ca^(2+) spiral waves by the local agonist in the cell membrane
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摘要 A modified spatially extended Tang-Othmer Ca2+ model is used to study intracellular Ca2+ spiral waves numerically. It is found that, as a local stimulation, the local agonist-binding on the cell membrane, which enhances the local concentration of the messenger molecule inositol 1,4,5-trisphosphate(IP3), can influence the dynamics of the spiral waves. 1) Strong enough stimuli can change the spiral wave from a meandering to a rigidly rotating one. 2) On the other hand, strong enough stimuli can suppress the spiral wave from the system. It provides the theoretical clue for controlling the spiral waves by stimulating the cell membrane. A modified spatially extended Tang-Othmer Ca2+ model is used to study intracellular Ca2+ spiral waves numerically. It is found that, as a local stimulation, the local agonist-binding on the cell membrane, which enhances the local concentration of the messenger molecule inositol 1,4,5-trisphosphate(IP3), can influence the dynamics of the spiral waves. 1) Strong enough stimuli can change the spiral wave from a meandering to a rigidly rotating one. 2) On the other hand, strong enough stimuli can suppress the spiral wave from the system. It provides the theoretical clue for controlling the spiral waves by stimulating the cell membrane.
出处 《Chinese Physics B》 SCIE EI CAS CSCD 2010年第3期145-149,共5页 中国物理B(英文版)
基金 Project supported by the Xuzhou Medical College Foundation,China (Grant No. 08kj08)
关键词 spiral wave local stimuli calcium signaling IP3 spiral wave, local stimuli, calcium signaling, IP3
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