病毒性脑炎血清心肌酶的变化及其临床意义

Changes and clinical significance of serum myocardial enzymes in patients with viral encephalitis

目的研究病毒性脑炎时血清心肌酶的变化及其临床意义。方法收集病毒性脑炎（病脑组）48例，另有体检正常者40例为对照组。采用东芝全自动生化分析仪，以酶速率法测定所有患者的血清天冬氨酸转氨酶（AST）、乳酸脱氢酶（LDH）、肌酸激酶（CK）、肌酸激酶心肌型同工酶（CK-MB）、a-羟丁酸脱氢酶（a-HBDH）水平。结果62．5％（30／48）病脑组血清心肌酶出现异常，与对照组比较差异有统计学意义（P〈0．01）；病脑组患者血清中AST、LDH、CK水平明显高于对照组（P〈0．05或〈0．01），病脑组CK-MB、a-HBDH水平与对照组比较，差异无统计学意义（P〉0．05）。结论病毒性脑炎常伴随心肌细胞损伤，血清心肌酶水平升高，对该类患者应常规行血清心肌酶测定。

Objective To explore the changes and clinical significance of serum myocardial enzymes in patients with viral encephalitis. Methods Forty-five patients suffering from virus encephalitis （ virus encephalitisgroup） were collected. Besides,40 health subjects served as control group. Serum aspartate aminotransferase （AST） , lactate dehydrogenase （LDH） , creatine kinase（CK） , muscle heart-acid kinase is oenzyme （CK-MB） , Ahydro xybutyric acid dehydrogenase （A-HBDH）of the patients were examined by TOSHIBA automaticbio chemical analyzer and enzymerate assay. Results the myocardial enzyme level of 62. 5% （ 30/48 ） of virus encephalitis group changed significantly compared with that of control group （ P 〈 0. 01 ） ; serum AST, LDH, CK levels of The myocardial enzymes of patients with cerebral functional disorder were significantly Higher than those of patients with normal cerebral function（ P 〈 0. 05 or 〈 0. 01 ）. There were no significant differences in the levels of CK-MB, A-HBDH of virus encephalitis group compared with those of control group （P 〉 0.05 ）. Conclusion Virus encephalitis is associated with myocardial injury, increased serum myocardial enzyme level. So, those patients should be measured of their routinely myocardial enzymes in the serum.