γ-芳亚甲氨基丙基杂氮硅三环的合成及其抗肿瘤活性研究

Studies on the Synthesis and Antitumour Activity of γ-(Arylideneamino)propylsilatranes

γ-氨基丙基杂氮硅三环与一系列芳香醛反应,合成了14种γ-芳亚甲氨基丙基杂氮硅三环化合物。用~1H NMR、IR、UV和元素分析确定了它们的化学结构。初步动物实验表明,某些化合物具有一定的抗肿瘤活性。

Fourteen γ-(arylideneamino)propylsilatranes were synthesized by the condensation of arylaldehydes with γ-aminopropylsilatrane in benzene. The structure of these new compounds were identified by 1H NMR, IR and UV as well as elemental analysis. Animal screening data show that the inhibition ratios of γ-(3-nitrobenzylideneamino)propylsilatrane, γ-(2-hydroxybenzylideneamino)pro-pylsilatrane, and γ-(2,4-dihydroxybenzylideneamino)propylsilatrane against Erlich ascites cancer in mice are 41.6%, 51.1% and 53.1%, respectively.