摘要
目的研究癫痫患者CYP2C19基因多态性。方法运用PCR-RFLP方法对67例应用丙戊酸的癫痫患者的CYP2C19*2和CYP2C19*3位点进行基因型分析。结果两个位点共有5种基因型组合:681GG-636GG、681GA-636GG、681GG-636GA、681AA-636GG、681GA-636GA。快代谢者(EMs)包括681GG-636GG、681GA-636GG、681GG-636GA基因型,分布频率为86.57%;慢代谢者(PMs)包括681AA-636GG、681GA-636GA基因型,分布频率为13.43%。结论PMs发生率与国内报道相近,CYP2C19基因多态性分析有助于丙戊酸的临床合理应用。
Objective To investigate the genetic polymorphism of CYP2Ct9 in patients with epilepsy. Methods CYP2C19 variants （ ＊ 2 and ＊ 3 ） were detected by PCR-RFLP method in 67 patients taking valproic acid. Results We found that there were five genotypes of CYP2C19 in these subjects,and that the frequencies of Extensive Metabolizers （EMs）were 86. 57% and the frequencies of Poor Metabolizers （PMs）were 13.43%. Conclusion The frequencies of PMs are similar to the data of the report. The genetic polymorphism analysis of CYP2C19 is helpful for the reasonable use of valproic acid.
出处
《中国实用医药》
2010年第5期51-52,共2页
China Practical Medicine
基金
广州市医药卫生科技项目(项目编号:2007-YB-212)
