广西学龄儿童流脑抗体水平和带菌情况分析

Research on Bacteria Carrying,Antibody Level and Control Strategy for Epidemic Eerebrospinal Meningitis in Guangxi

目的掌握广西学龄儿童中流脑抗体水平和咽部带菌情况,为探讨流脑防制策略提供科学依据。方法在广西柳州市、百色市、贵港市和合浦县4地的学龄人群中分层整群抽样,抽取12所学校12个班级共367名学生;采集咽拭子和血液标本,进行咽拭子培养和血液抗体水平检测。结果学龄人群流脑疫苗接种率为60.49%;咽喉部脑膜炎奈瑟菌带菌率为5.72%,流脑A群、C群、W135群、Y群抗体保护阳性率分别为87.67%,74.52%,36.61%,42.08%。城镇学龄人群的疫苗接种率、A/C/Y群抗体水平都显著性高于农村学龄人群。结论广西学龄人群对A群和C群流脑有一定抵抗力,对W135和Y群流脑的免疫力相对较低且存在自然感染;农村寄宿学生为高危人群。

Objective To understand the situation of bacteria carrying and antibody level on epidemic meningitis in Guangxi,and to offer the evidence for the development of control strategy.Methods Stratified cluster random sampling was applied in the survey which was conducted in schools in Liuzhou,Baise,Guigang and Hepu county in Guangxi.There were 367 students totally sampled among 12 classes in 12 schools.Throat swab and serum specimens were collected for culture and antibody level test respectively.Results The vaccination rate was 60.49% among the school-children and carrying rate was 5.72% observed in throat swab culture.The antibody protection positive rate of 87.67%,74.52%,36.61% and 42.08% were reported among the A group,C group,W135 group and Y group antibody for Nm respectively.Both the vaccination rate and the antibody level were better than the rural population.Conclusions There is certain immunity for A group and C group Nm among school age population in Guangxi,and immunity for W135 group and Y group is relative low and exist natural infection.The rural boarding students are the high risk population.