MOAP方案治疗急性淋巴细胞白血病疗效观察

Effects of MOAP regimen on acute lymphoblastic leukemia

目的观察MOAP方案治疗急性淋巴细胞白血病(ALL)的近期疗效和不良反应。方法我科于2003年1月-2008年12月应用MOAP方案治疗30例ALL,对照组用TOLP方案,2个疗程评价化疗方案的疗效,同时记录不良反应。结果MOAP组治疗初治ALL缓解率90.9%,对照组86.2%。MOAP组达到缓解的时间(15.7±6.4)d,对照组(19.8±3.2)d。MOAP组感染率、药物不良反应均低于对照组。结论MOAP方案治疗ALL有良好的疗效,且耐受性好。

Objective To elucidate the effects and toxicity of MOAP regimen on acute lymphoblastic leukemia （ALL）. Methods Thirty patients with ALL were treated with MOAP regimen and 35 patients were treated with TOLP regimen. The effects and toxicity were evaluated after 2 courses of treatment. Results The overall response rate （ORR） for MOAP treatment and control groups was 90.9%and 86.2%, respectively （P0.05）. The overall response time of MOAP treatment and control groups was 15.7±6.4 days and 19.8±3.2 days, respectively（P0.05）. The infection rate, hemotology and non- hemotology toxicity were lower in MOAP treatment group than in control group. Conclusion Better curative effect and tolerance can be achieved in treatment of ALL with MOAP regimen than with TOLP regimen.