微生物甲醛脱氢酶的研究进展

Research Advances on Formaldehyde Dehydrogenase from Microorganisms

甲醛脱氢酶(FADH)属于中等锌链醇脱氢酶家族中的一员,存在于绝大多数原核生物以及所有的真核生物中,是微生物中主要用于甲醛解毒的酶。近年来一些研究确定甲醛脱氢酶还具有S-亚硝基谷胱甘肽还原酶(GSNOR)的活性,用于调节内源性NO的动态平衡。对微生物甲醛脱氢酶的结构,生理生化特性,基因克隆以及在环保上的应用方面进行综述。

Formaldehyde dehydrogenase （FADH） is a member of the zinc-containing medium chain alcohol dehydrogenase family and has been found in all eukaryotes and most prokaryotes, acting as a main enzyme for formaldehyde detoxification in microorganisms. Recently,several researches established that FADH exhibited S-nitroglutathione reductase （GSNOR） activity to regulate the NO homeostasis. This paper reviewed the research progresses in FADH structure, physiological and biochemical features, gene cloning and environment application.