烟酸缓释片对患者血脂及C-反应蛋白水平的影响

Effect of extended-release niacin on the dyslipoproteinemia and levels of serum C-reactive

目的观察烟酸缓释片对患者血脂及血清C-反应蛋白(CRP)水平的影响。方法采用前后对照方法,对56名血脂异常患者予口服烟酸缓释片单药治疗,前4周每日睡前服用1次,每次1片(0.5g);4周后所有患者调整剂量,增加为每日睡前服用1次,每次2片(1.0g)。分别于治疗前、治疗后4周及8周检查患者血脂及CRP并评估疗效及不良反应。结果56例患者应用烟酸缓释片治疗4周后,甘油三酯(TG)降低10.2%,高密度脂蛋白胆固醇(HDL-C)升高12.2%,CRP降低19.6%;8周后,TG降低27.1%,HDL-C升高16.7%(均P<0.05)。CRP降低27.3%(P<0.05)。不良反应以潮红(12.5%)和消化道症状(21.1%)较常见,对肝肾功能影响无统计学意义。结论烟酸缓释片能有效地调节血脂,尤以降低TG和升高HDL-C效果明显,能较好的降低CRP,耐受性好、安全性高,是控制冠心病高危因素较好的药物,且医药费用低。

Objective To investigate the effect of extended - release niacin （niacin ER） on dyslipoproteinemia and levels of serum C - reactive protein （CRP）. Methods 56 patients with dyslipoproteinemia were given niacin ER 500 mg/d for 4 weeks and then 1000 mg/d for 4 weeks. The serums lipid profiles and CRP and adverse effects were assessed in all the patients before treatment, and 4 and 8 weeks after treatment. Results After treatment of 4 weeks, the levels of TG and CRP decreased 10.2% and 19.6% respectively compared with the level of baseline, and the HDL- C increased 12.2%. After treatment of 8 weeks, the levels of TG and CRP decreased significantly 27.1% and 27.3%, respectively （P〈0.05）, and the HDL-C significantly increased 16.7% （P〈0. 05）. There were blood flushes （ 12.5% ） and digestive symptom （21.1%） and non - statistics significance to the hepatorenal function in adverse effects. Conclusion Niacin ER has a favorable effect on modulating the blood lipid profile, especially reducing TG and elevating HDL - C, and decreasing levels of CRP, with safety and well tolerablity.