摘要
目的 研究慢性阻塞性肺病(COPD)患者肺血流动力学改变与血生长因子水平变化之间的关系。方法应用右心漂浮导管测量肺动脉压和肺毛细血管楔压,ELISA法测定血小板衍生生长因子(PDGF)水平。结果观察12例COPD急性发作期患者血PDGF-AB(3.90±0.67g/L,P<0.001),较正常对照组有较明显升高,与平均肺动脉压呈正相关,(r0.79,P<0.01);与动脉血气pH、PaO2呈负相关,与PaO2呈正相关,与肺毛细血管楔压改变的相关性无显著意义。讨论PDGF在COPD患者急性发作期血水平升高且与肺动脉压的变化呈正相关,提示这种生长因子可能与COPD肺动脉庙坟的形成有些联系,并可能参与肺动脉高压发生中肺血管结构的重构过程。
Object: To research the correlation between the blood plasma Platelet-derived growth factor-AB (PDGF - AB) alterations and the pulmonary hemodynamic in COPD patients during acute exaceration. Method: The mean pulmonary artery pressure (mPAP) and pulmonary capillary wedge pressure (CPWP) were measured by swan-ganz catheterization. The blood plasma PDGF-AB were measured by ELISA. Result: The blood plasma PDGF-AB (3.90±0.67ng/L, P<0.001) raised significantly in 12 patients than the normal persons. The correlation between the PDGF-AB and mPAP (r= 0.79,P<0. 01)、the PDGF-AB and PaCO2 (r = 0.79 P<0.05)、the PDGF-AB and pH (r = 0. 60 P<0.05)、 the PDGF-AB and Pa-CO2 (r = 0.70P<0.05) were significant. Conclusion: The results supported that the PDGF was related to the pathogenesis of pulmonary hypertension in COPD patients. It may involved the pulmonary vascular remodeling.
