山东省艾滋病抗病毒治疗病例服药依从性及相关影响因素调查

Investigation on Adherence to Antiretroviral Therapy and Influence Factors of AIDS Patients in Shandong Province

[目的]了解山东省艾滋病抗病毒治疗病例服药依从性情况及其相关影响因素。[方法]对山东省2009年4月1日至9月31日正在接受抗病毒治疗的324例艾滋病病例进行治疗依从性及相关因素调查,并对治>6个月的病例进行病毒载量检测。[结果]治疗324例病人中,94.75%服药依从性良好;服药依从性差前2位原因为因事耽误(7例)和药物副作用(5例)。227例服药依从性好的病例治疗6个月后,病毒载量<400 cp/ml的占88.55%,这一比例在依从性差的12例病人中为66.67%(P>0.05)。5例有药物副作用者4例病毒载量值>10 000 cp/ml。[结论]山东省艾滋治疗病例服药整体依从性良好,药物的副作用应引起注意。

[Objective]To investigate the AIDS patients＇ adherence of antiretroviral therapy （ART） and influence factors in Shandong province. [Methods]Investigation on the adherence and influence factors of AIDS patients on ART treatment was conducted in Shandong from April 1st to September 31st 2009, and viral load test was carried out for the patients who on HAART（High Activ＇e Antiretroviral Therapy） more than 6 months. [Results]94.75 % of the patients（324） have good adherence in Shandong province. Delayed by something（7） and adverse reaction（5） are main reasons for poor adherence. The viral load of 88.55 % （227）patients with good adherence descended to 400cp/ml or even lower, while only 66.37% （12）patients＇ viral load dropped to 400 cp/ml with poor adherence. The viral load of the 4 patients with adverse reaction （5） were higher than 10 000 cp/ml. [Conclusion]Generally, adherence is good in Shandong Province, but we should pay more attention to the adverse reaction.