肠道病原性大肠杆菌和宿主细胞间的相互作用

The Interaction between Enteropathogenic Escherichia coli and Host Cells

肠道病原性大肠杆菌(EPEC)属于胞外菌,主要通过粘附在肠上皮细胞上引起宿主的发病。EPEC形成基座、产生粘附和脱落(A/E)损伤的细菌因子、导致宿主信号转导改变的途径及其发病机制的遗传基础都已经得到广泛的研究。对近年来关于EPEC和宿主细胞间的相互作用的研究进展进行总结,并着重论述EPEC对于肠上皮细胞紧密连接的影响。

Enteropathogenic Escherichia coli（EPEC） is an extracellular bacteria,primarily through adhere to host intestinal epithelial cells caused pathogenesis.EPEC can produce pedestals,and the bacterial factors involved in attaching and effacing（A/E） lesion formation,modulates several signal transduction pathways within the host cells and the genetic basis of EPEC pathogenesis have been widely studied.This review describes the recent studies of enteropathogenic（EPEC） interact with host cells,and intensively discusses the influence of EPEC to tight junctions between cells.