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影响肺腺癌预后因素的研究

The Influencing Factors of Prognosis in Lung Adenocarcinoma
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摘要 应用多功能图像分析仪,对34例术后生存时间有明显差异的肺腺癌标本进行检测,并应用免疫组化方法检测了P53蛋白的异常表达,探讨与预后之间的关系。结果显示:DNA含量、核面积(NA)、核周长(NP)、最大直径(Dmax)、最小直径(Dmin)、等效直径(ED)、核形态指数(NFI)、核面积标准差(NASD)及核周长标准差(NPSD)9项参数与患者预后有显著关系(P<0.05),核积分光密度标准差(NIS)和核轴比(NAR)2项参数与患者预后无关(P>0.05);P53蛋白阳性表达者预后显著差于P53蛋白阴性表达者(P<0.05);DNA值与NA呈显著正相关,与NFI呈显著负相关。表明细胞核量测定和P53蛋白免疫组化检测在肺腺癌预后判断中具有重要意义。 Nuclear morphometry was performed with image analysis technique and the expression of P53 protein was detected with immunohistochemical technique in 34 cases of lung adenocarcinoma which involved patients with long and short survival time.The results showed that DNA,NA,NP,Dmax,Dmin,ED,NFI,NASD and NPSD were significantly correlated with survival time but NIS and NAR were not.The survival time of patients with P53negative was longer than that with P53positive.There was significantly positive correlation between DNA and NA,and negative correlation between DNA and NFI.This suggested that nuclear morphometry and P53protein immunohistochemical detection had important value in predicting prognosis of patients with lung adenocarcinoma.
出处 《齐鲁肿瘤杂志》 1998年第1期14-16,共3页
关键词 肺肿瘤 腺癌 预后 形态测定 P53基因 Pulmonary neoplasms Adenocarcinoma Prognosis P53 Morphometry
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