胃粘膜肠化、异型增生和胃癌组织粘液组化及PCNA表达的相关分析

The Study of the Correlation between Mucin Histochemistry and PCNA in Patient Tissues With Intestinal Metoplasia,Allotype Hyperplasia and Gastric Cancer

本文对３４例胃粘膜肠化、３２例异型增生、２２例胃癌行粘液化及ＰＣＮＡ免疫组化研究。结果表明：唾酸粘液阳性与肠化、异型增生、胃癌呈负相关，而硫酸粘液阳性呈正相关。ＰＣＮＡ阳性、肠化与异型增生及胃癌差异有显著意义（Ｐ＜０．０５），而异型增生与胃癌差异无显著意义（Ｐ＞０．０５）。唾酸粘液阳性者，ＰＣＮＡ阳性率为２６．３％，而硫酸粘液阳性者为９２．０％，两者有非常显著差异（Ｐ＜０．０１）。

34 cases with intestinal metoplasia,32 cases with allotype hyperplasia,22 cases with gastric cancer were studied with mucin histochemistry and PCNA.The results suggested that salivary mucin positive was negtively correlated with intestinal metoplasia,allotype hyperplasia and gastric cancer,but sulfomcin positive was positively correlated with them.There were significant correlations between PCNA positive,intestinal metoplasia,allotype hyperplasia and gastric cancer(P<0.05).There was no difference between allotype hyperplasia and gastric cancer.In salivary mucin positive cases,PCNA positive rate was 26.3%,sulfomucin positive rate was 92.0%,there was a prominent difference between them(P<0.01).